Analysis reveals an association between dopamine transporter binding and tremor in patients with Parkinson disease, suggesting a link between motor symptoms and brain chemistry.
The mechanisms underlying tremor generation in Parkinson disease (PD) remain unclear. Previously, we demonstrated a connection between rest tremor amplitude and higher dopamine transporter (DAT) binding in the ipsilateral striatum among the Parkinson Progression Markers Initiative cohort. Here, we investigated the association of parkinsonian motor symptoms with striatal DAT binding in a sizable and clinically representative sample of patients with parkinsonian signs to validate the previously observed ipsilateral relationship in PD.
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Niemi et al. (2026) studied this question.
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