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Research demonstrates that resveratrol pretreatment modulates SUR1-TRPM4 expression during oxygen-glucose deprivation in brain cells, suggesting a protective strategy.
SUR1-TRPM4 becomes functionally expressed in a subset of HBEC-5i during OGD/R and pretreatment with Resveratrol attenuated this response. Early modulation of SUR1-TRPM4 by Resveratrol may represent a potential strategy to limit ionic edema.
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Burgos et al. (2026) studied this question.
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