Synergistic Nanoemulgel-based Micro/Nanosystems in Transdermal Delivery: Advances in Herbal-Synthetic Combination Therapies

There are several challenges associated with the increasing use of lipophilic medications, including limited oral bioavailability, irregular absorption, and unpredictable pharmacokinetics. Nanoemulgels, an innovative transdermal drug delivery technology, have shown significant potential in improving the permeability and bioavailability of such medications. By combining the advantages of nanoemulsions and gels, nanoemulgels provide an effective method for topical drug application, helping to overcome issues related to targeting and absorption. This review examines the use of nanoemulgels in the management of inflammatory conditions, particularly gout. Colchicine, a BCS Class III medication with restricted permeability, is used as a case study to explore formulation techniques, procedures, and excipients aimed at optimizing nanoemulgel systems. The review highlights permeability enhancement mechanisms and the potential of nanoemulgels for targeted antiinflammatory drug delivery, emphasizing their promise as a novel therapeutic strategy for inflammatory diseases.