This research demonstrates efficient cytosolic delivery of biomacromolecules using reconfigurable nanovectors, highlighting potential in drug delivery technologies.
Protein-Inspired Reconfigurable Nanovector-Based Coacervates Intrinsically disordered protein–inspired nanovectors undergo reversible conformational transitions that enable coacervate formation with diverse biomacromolecules. The resulting nanocoacervates remain stable under physiological conditions and can directly penetrate cellular membranes through the dynamic motion of the nanovectors. This platform supports efficient cytosolic delivery of a wide range of cargos, providing a versatile approach for intracellular transport technologies. More details can be found in the Research Article by Kwan Hyi Lee, Ja-Hyoung Ryu, Youngdo Jeong, and co-workers (DOI: 10.1002/adma.202507877).
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Jin et al. (2026) studied this question.
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