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March 22, 2026Journal of Exploratory Research in PharmacologyOpen Access

Potential Natural Products for the Treatment of Diabetic Cardiomyopathy: Advances and Outlooks

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Why the study?

Current treatments for diabetic cardiomyopathy face challenges including limited efficacy and adverse effects, while early diagnosis remains difficult.

Design

Review

Key result

Natural products demonstrate multitarget therapeutic potential for treating diabetic cardiomyopathy by alleviating oxidative stress, inflammation, and myocardial fibrosis across various preclinical models.

Authors

RZRunli ZhaoHLHaoyang LiYZYu Zhao

Discussion

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Overview

Should not yet change diabetic cardiomyopathy practice; extends preclinical natural product evidence but leaves clinical efficacy unconfirmed.

Key Points

  • The aim is to summarize the pharmacological effects and molecular mechanisms of natural products on diabetic cardiomyopathy.
  • Systematic review of literature from the past five years
  • Analysis of various natural products including flavonoids, terpenoids, and alkaloids
  • Discussion of molecular mechanisms related to treatment of DCM
  • Natural products demonstrate potential in preventing DCM
  • These compounds target multiple pathways involved in DCM
  • Findings highlight the need for further research in natural product drug development

Structured PICO

P
Population
Diabetic cardiomyopathy (DCM)
I
Intervention
Natural products (e.g., flavonoids, terpenoids, phenylpropanoids, alkaloids, and polysaccharides)

Natural products offer a promising multitarget therapeutic approach for the prevention and treatment of diabetic cardiomyopathy by modulating oxidative stress, inflammation, and apoptosis.

Limitations

  • Current conventional interventions often fail to fully arrest or reverse the deterioration of myocardial structure and function.
  • Existing pharmacological agents are limited by off-target complications, such as an increased risk of genitourinary tract infections with SGLT2 inhibitors.

Cite This Study

Zhao et al. (2026) conducted a review in Diabetic cardiomyopathy. Natural products (flavonoids, terpenoids, phenylpropanoids, alkaloids, polysaccharides) was evaluated. Natural products demonstrate multitarget therapeutic potential for treating diabetic cardiomyopathy by alleviating oxidative stress, inflammation, and myocardial fibrosis across various preclinical models.

synapsesocial.com/papers/69bf8692f665edcd009e8f17https://doi.org/10.14218/jerp.2025.00063
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