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March 1, 2026IBRO Neuroscience ReportsOpen Access

TGF-β1 modulates PFC glial cell activation to facilitate exercise-induced analgesia in mice with spared nerve injury

Yan Kong Junqi Wu Xinzheng Sun Chenghao Wang Hui He

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Key Points

This study aims to clarify the role of the prefrontal cortex in exercise-induced analgesia and the involvement of TGF-β1 signaling and astrocytes.
Used a spared nerve injury model in C57BL/6J mice.
Mice underwent low-intensity aerobic treadmill training.
Assessed mechanical and cold pain behaviors.
Performed molecular and histological analyses of the prefrontal cortex.
SNI caused mechanical and cold pain hypersensitivity in mice (P<0.01).
Exercise significantly reduced pain hypersensitivity (P<0.01) and restored TGF-β1 expression (P<0.01).
Astrocyte activation decreased with exercise (P<0.05) and TGF-β1-astrocyte co-localization increased.
TGF-R inhibition attenuated exercise analgesia and enhanced astrocyte activation (P<0.01).

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Implication

A study investigates how exercise modulates pain through TGF-β1 signaling in a neuropathic pain model.

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Cite This Study

Kong et al. (2026) studied this question.

synapsesocial.com/papers/69bf86ecf665edcd009e906c https://doi.org/10.1016/j.ibneur.2026.03.009

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