Expert variability as a benchmark for validating automatic CT–MRI registration in brain stereotactic radiosurgery

Valeria Faccenda; Denis Panizza; Valentina Pinzi; Stefano Carminati; Riccardo Ray Colciago; Stefano Alberto Mascellani; Bianca Bordigoni; Ilenia Manno; Matteo Mombelli; V. Pierini; Alicia Rejas Mateo; Elena de Martin; Elena De Ponti; Stefano Arcangeli

doi:10.1016/j.ejmp.2026.105765

March 19, 2026Physica MedicaOpen Access

Expert variability as a benchmark for validating automatic CT–MRI registration in brain stereotactic radiosurgery

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Key Points

The research aims to quantify expert variability to establish benchmarks for validating CT-MRI registration in brain radiosurgery.
Assessed multi-expert variability in CT-MRI registration.
Developed a probabilistic framework for algorithm validation.
Evaluated an AI-driven convolutional neural network (CB) algorithm in practical scenarios.
Established clinically relevant thresholds for CT-MRI registration accuracy.
Demonstrated high reliability of the AI-driven algorithm across scenarios.
Showed reduced operator dependence in CT-MRI registration processes.

Implication

Quantifying expert variability validates CT-MRI registration in brain stereotactic radiosurgery, suggesting improved workflows with AI algorithms.

Abstract

Quantifying multi-expert variability enables a probabilistic GS and clinically relevant thresholds for CT-MRI registration. This benchmark reflects human performance and provides a framework for algorithm validation. An AI-driven CB algorithm demonstrated high reliability, reduced operator dependence, and may streamline SRS workflows.

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Cite This Study

Faccenda et al. (2026) studied this question.

synapsesocial.com/papers/69bf86ecf665edcd009e915f https://doi.org/10.1016/j.ejmp.2026.105765

View Full Paper

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Expert variability as a benchmark for validating automatic CT–MRI registration in brain stereotactic radiosurgery

Key Points

Implication

Abstract

Discussion

Cite This Study

Expert variability as a benchmark for validating automatic CT–MRI registration in brain stereotactic radiosurgery

Key Points

Implication

Abstract

Discussion

Cite This Study

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