Can fluconazole be used to treat non-resistant Candida (Candidozyma) auris infections? Preclinical PK/PD data from a Galleria mellonella infection model

Key Points

• This research aims to evaluate the effectiveness of fluconazole against non-resistant strains of C. auris using preclinical models.
• Utilized an in vivo infection model with Galleria mellonella.
• Assessed fluconazole activity against both C. auris and C. albicans.
• Determined the minimum inhibitory concentrations (MICs) for wild-type isolates.
• Fluconazole showed comparable in vivo activity against C. auris and C. albicans.
• Wild-type isolates with MICs of ≤8 mg/L could potentially be treated with doses of 1,200 mg/day.