Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

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Ceragenin-coated endotracheal tubes do not significantly reduce the incidence of ventilator-associated pneumonia compared to subglottic suction tubes, but they are associated with improved secondary clinical outcomes including lower mortality and increased ventilator-free days. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

John Muscedere; Patrick A. Norman; Christine D’Arsigney; A. C. Day; J. Gordon Boyd; Tracy Boyd; D. Maslove; Stephanie Sibley; Carrie L. Shorey

doi:10.1097/cce.0000000000001382

March 20, 2026Critical Care ExplorationsOpen Access

Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

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Key Points

This study aims to assess the effectiveness of ceragenin-coated endotracheal tubes in reducing ventilator-associated pneumonia in critically ill patients.
Prospective crossover design with interrupted time series implementation.
Conducted in a medical-surgical ICU setting.
Comparison between patients receiving ceragenin-coated endotracheal tubes and standard suction endotracheal tubes.
Measurement of primary and secondary outcomes including rates of VAP and mortality.
VAP occurred in 19% of patients with ceragenin-coated tubes compared to 15% with standard tubes (p=0.40).
Patients with ceragenin-coated tubes had more antibiotic-free days (14.7 days vs. 11.8 days, p=0.047).
Higher ventilation-free days observed in the ceragenin group (15.7 days vs. 12.4 days, p=0.03).
Lower ICU mortality rates (20% vs. 36%, p=0.01) and hospital mortality (25% vs. 43%, p=0.004) in the ceragenin group.

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Implication

Prospective study evaluates ceragenin-coated endotracheal tubes reducing pneumonia incidence in critically ill adults, suggesting potential clinical benefits.

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Cite This Study

Muscedere et al. (2026) studied this question.

synapsesocial.com/papers/69bf898bf665edcd009e948f https://doi.org/10.1097/cce.0000000000001382

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Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study)

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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