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March 22, 2026Current Organic Chemistry

A Comprehensive Insight into the Synthetic Pathways to Tetrahydrobenzoxazepines, Tetrahydrobenzothiazepines, and Tetrahydrobenzoimidazoazepines

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Authors

ABAditya BhattacharyyaASAshis Kumar Sahoo

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Overview

This review discusses advances in synthesizing key heterocycles, indicating improved methodologies for diverse compounds.

Key Points

  • The aim is to summarize advancements in the synthesis of tetrahydrobenzoxazepines, tetrahydrobenzothiazepines, and tetrahydrobenzoimidazoazepines.
  • Review of synthetic methodologies for heterocycles
  • Discussion of cyclodehydration and C-N bond formation
  • Analysis of ring-expansion and cyclization strategies
  • Evaluation of reaction conditions under green chemistry metrics
  • Significant improvements in yield and efficiency of synthetic pathways
  • Diverse methodologies explored over two decades
  • High regio- and stereocontrol achieved through intramolecular C-N coupling
  • New approaches allow rapid diversification of heterocyclic libraries

Cite This Study

Bhattacharyya et al. (2026) studied this question.

synapsesocial.com/papers/69bf898bf665edcd009e94c5https://doi.org/10.2174/0113852728394398251007105546
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