Using the complete FlyWire v783 connectome (N=138, 639 neurons; E=15, 091, 983 synapses), four parameter-free neural models, and two null-model families (Maslov-Sneppen, N=100; community-preserving, N=5-10), we characterize three signal propagation properties of the Drosophila melanogaster brain. (1) Active Intermodal Isolation. The topology separates sensory signals via directed inhibition (contralateral cancellation =1. 37). During stimulus, separation is largely explained by generic modular structure ; post-stimulus amplification requires specific wiring (Z₂=+14. 8). (2) Differential Motor Access by Concentration. Somatosensory neurons exhibit privileged motor access (=+0. 365, p₄ₑ₌<0. 01). Canonical gustatory neurons alone produce significant privilege (Z=+4. 5), although the effect is dominated by mechanosensory neurons (95. 2%). Density analysis reveals that 7/10 sensory classes have motor access inferior to density expectation: the topology concentrates connections onto the somatosensory pathway rather than adding them. (3) Non-Trivial Temporal Amplification. Under graded dynamics, RDI rises from 0. 63 to 0. 83 post-stimulus, an effect that survives the community-preserving control (Z₂=+14. 8), confirming dependence on fine wiring—including reciprocity (36x over density expectation). The parameter =0. 119 corresponds to ₘ8. 4 ms, center of the Drosophila physiological range.
Jorge Abraham Mendieta (Fri,) studied this question.