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May 15, 2026

Single or Double Embryo Transfer for Infertility: An Evaluation of Registry Data From Over 22 000 Treatment Cycles.

Jan-Steffen Krüssel Markus Kimmel Ute Czeromin Verona Blumenauer Sylvia Anna Bartnitzky Nicole Sänger Daniel Fehr Christoph Grewe Markus Simon Kupka Sascha Tauchert Holger Aust Andreas Tandler-Schneider

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Key Points

This research aims to compare the effectiveness and risks of single versus double embryo transfer in infertility treatments.
Analysis of registry data from over 22,000 treatment cycles
Comparison of success rates between single embryo transfer (SET) and double embryo transfer (DET)
Assessment of associated risks with each transfer method.
Two consecutive single embryo transfers show similar success rates to double embryo transfer
SET significantly reduces risks compared to DET while maintaining comparable birth outcomes.

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Implication

Registry data evaluates success rates and risks in infertility treatments comparing single and double embryo transfer.

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Cite This Study

Krüssel et al. (2026) studied this question.

synapsesocial.com/papers/69bf89a9f665edcd009e9915 https://doi.org/10.3238/arztebl.m2026.0025

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Single embryo transfer is an option in frozen embryo transferRetrospective Study · 2005 · 56 citations
2O-090 The paradox of choice in double (DET) versus single (SET) embryo transfer: more is less!2024
3P-745 effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from UK HFEA registry2024
4One Plus One is Better than Two: An Approach Towards a Single Blastocyst Transfer Policy for All IVF PatientsRetrospective Study · 2022 · 3 citations
5Single vs. double good-quality embryo transfer in fresh cleavage-stage cycles: a propensity score-matched analysis of efficacy and risksCohort Study · 2026

Transfer Strategy Minimizing Twin Risk of Double Blastocyst Transfers Based on Prediction Models2026
In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial2005
O-241 ESHRE guidance on embryo transfer: when to do DET?2024