October 12, 2004Circulation
Impact of Prior Use or Recent Withdrawal of Oral Antiplatelet Agents on Acute Coronary Syndromes
Why the study?
Does prior use or recent withdrawal of oral antiplatelet agents affect clinical presentation and outcomes in ACS patients?
Population
ACS patients
Comparison
Prior use or recent interruption of oral… vs Nonusers of OAA and chronic OAA users
Design
Cohort
Authors
Discussion
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Member takes
Implication
Recent OAA interruption was associated with worse ACS outcomes; hypothesis-generating and should not yet change practice.
Structured PICO
Does prior use or recent withdrawal of oral antiplatelet agents affect clinical presentation and outcomes in ACS patients?
P
Population
ACS patients
I
Intervention
Prior use or recent interruption of oral antiplatelet agents (OAA)
C
Comparator
Nonusers of OAA and chronic OAA users
O
Outcome
Clinical outcomes and ACS presentation type (non-ST-elevation ACS)
Recent interruption of oral antiplatelet therapy prior to an acute coronary syndrome is associated with worse clinical outcomes compared to chronic use.
Cite This Study
Collet et al. (2004) studied this question.