Does prior use or recent withdrawal of oral antiplatelet agents affect clinical presentation and outcomes in ACS patients?
Recent interruption of oral antiplatelet therapy prior to an acute coronary syndrome is associated with worse clinical outcomes compared to chronic use.
Among ACS patients, prior users represent a higher-risk population and present more frequently with non-ST-elevation ACS than nonusers. Although patients with a recent interruption of OAA resemble those chronically treated by OAA, they display worse clinical outcomes.
Collet et al. (Tue,) studied this question.