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March 19, 2026International Dental JournalOpen Access

Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis

Xuanhe Feng Liang Hu Chen Zhang Wanzhen Lei Bowen Zhou Di Xia Zhaochen Shan Luyuan Jin

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Key Points

The study aims to explore how targeting the AKT/eNOS signalling axis can improve dentin regeneration in diabetic conditions.
Targeted the AKT/eNOS signalling pathway.
Assessed effects on dentin regeneration in diabetic models.
Evaluated therapeutic potential for enhancing regeneration.
Enhanced dentin regeneration observed in diabetic conditions.
Significant improvement in regenerative outcomes through AKT/eNOS axis targeting.
Indicated potential for a novel therapeutic strategy in diabetic patients.

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Implication

Findings demonstrate enhanced dentin regeneration in diabetic patients by targeting the AKT/eNOS axis, indicating a new therapy.

Abstract

Targeting the AKT/eNOS signalling axis offers a novel therapeutic strategy to enhance dentin regeneration in diabetic patients.

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c1102 https://doi.org/10.1016/j.identj.2026.109511

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