What question did this study set out to answer?

To investigate the association between HE4 levels and the risk of future venous thromboembolism (VTE).

March 23, 2026Journal of Thrombosis and Haemostasis0 citationsOpen Access

Plasma level of human epididymis protein 4 is associated with risk of future venous thromboembolism – The HUNT Study

CCCelina Janene CathroUiT The Arctic University of Norway EEEllen-Sofie Wulff EilertsenThrombosis Research Institute TNTherese H. NøstLevanger Hospital

Puntos clave

To investigate the association between HE4 levels and the risk of future venous thromboembolism (VTE).
Analyzed plasma HE4 levels in participants of the HUNT Study.
Adjusted findings for major confounders to determine risk association.
Evaluated the genetic regulation of HE4 levels.
HE4 levels were linked to increased risk of future VTE.
The relationship remained after controlling for confounding factors.
HE4 levels do not appear to be strongly genetically regulated.

Resumen

HE4 levels were associated with increased risk of future VTE after adjustments for major confounders and appeared not to be strongly genetically regulated. Our findings suggest that HE4 levels might reflect an underlying condition, e.g. oxidative stress, predisposing to VTE.

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Cite This Study

Cathro et al. (Sun,) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c1130 https://doi.org/https://doi.org/10.1016/j.jtha.2026.03.009

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