Apical hyperosmotic challenge upregulates aquaporin-3 in human airway epithelia

Alexander Sauter; Oliver H. Wittekindt; Lara Anabell Gutjahr; Ronja Rössel; Manfred Frick; S Bode; Hanna Schmidt

doi:10.1016/j.jcf.2026.03.013

March 1, 2026Journal of Cystic FibrosisOpen Access

Apical hyperosmotic challenge upregulates aquaporin-3 in human airway epithelia

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Key Points

This research investigates how hyperosmotic conditions affect aquaporin-3 regulation in airway epithelial cells.
Examined the response of airway epithelia to apical hyperosmotic challenge.
Assessed the role of ENaC in aquaporin-3 regulation.
Evaluated the involvement of calcium signaling in the regulation process.
Hyperosmotic conditions significantly increased aquaporin-3 expression.
AQP3 upregulation is linked to ENaC and calcium pathways.
Suggests a protective mechanism for fluid reabsorption after secretion.

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Implication

Apical hyperosmotic conditions upregulate aquaporin-3 in airway epithelia, indicating a mechanism for fluid balance.

Abstract

We conclude, that apical hyperosmotic conditions up-regulate AQP3 in airway epithelia via an ENaC and calcium dependent pathway. Probably, AQP3 regulation provides a counteractive mechanism that drives fluid reabsorption after osmotically induced fluid secretion.

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Cite This Study

Sauter et al. (2026) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c114d https://doi.org/10.1016/j.jcf.2026.03.013

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Apical hyperosmotic challenge upregulates aquaporin-3 in human airway epithelia

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Apical hyperosmotic challenge upregulates aquaporin-3 in human airway epithelia

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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