Masked alterations of glucose metabolism among patients awaiting kidney transplantation: Metabolic phenotyping and screening strategies

Elena Terán-García; Lourdes Perez-Tamajón; Claudia Rodríguez-López; Arminda Fariña-Hernández; Estefanía Pérez-Carreño; Domingo Marrero-Miranda; Cristian Acosta-Sorensen; Antonia M de Vera-González; Alejandra González-Delgado; Ana Elena Rodríguez-Rodríguez; Sagrario García-Rebollo; Concepción Rodríguez-Adanero; Alejandra Álvarez-González; Ana Gonzalez-Rinne; Antonio Rivero-González; Manuel Luis Macia-Heras; Aurelio P. Rodríguez-Hernández; Eduardo De Bonis-Redondo; Esteban Porrini; Domingo Hernández-Marrero; Armando Torres

doi:10.1016/j.nefroe.2026.501465

Key Points

This research aims to identify hidden changes in glucose metabolism among patients on the transplant waitlist.
Analyzed glucose metabolism using oral glucose tolerance tests (OGTT)
Assessed risk factors like age, fasting glucose, and statin use
Evaluated the need for routine testing based on specific thresholds
One-third of patients awaiting transplants show abnormal OGTT results despite no diabetes symptoms
Younger patients without high fasting glucose and statin use have lower abnormal OGTT likelihood
Annual OGTT testing may be recommended for overweight/obese patients who initially test normal

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Metabolic phenotyping reveals abnormal glucose tests in patients awaiting kidney transplants, suggesting improved screening strategies.

Abstract

One-third of wait-listed patients without manifest diabetes exhibit abnormal OGTT. Age, fasting glucose, and statin use increase risk. Patients below age and fasting glucose thresholds, without statins, have low abnormal OGTT likelihood, potentially reducing routine testing. Annual OGTT may benefit patients initially with normal results, if overweight/obese, or on statins.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Terán-García et al. (2026) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c1168 https://doi.org/10.1016/j.nefroe.2026.501465

View Full Paper

Ask AI

Bookmark

Share

Masked alterations of glucose metabolism among patients awaiting kidney transplantation: Metabolic phenotyping and screening strategies

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Masked alterations of glucose metabolism among patients awaiting kidney transplantation: Metabolic phenotyping and screening strategies

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading