Key result
Natural compounds may mitigate sepsis-related cardiac dysfunction by modulating immune crosstalk and inhibiting cell death.
Why the study?
Sepsis-related cardiac dysfunction is a severe complication of sepsis involving complex pathophysiology, including dysregulated inflammatory responses, immune cell dysfunction, and programmed cell death.
This review outlines the pathophysiological mechanisms of sepsis-related cardiac dysfunction, emphasizing the NETs-macrophage pyroptosis feedback loop and the therapeutic potential of natural compounds.
Should not change practice in sepsis-related cardiac dysfunction; leaves open therapeutic role of natural compounds pending RCTs.
Sepsis-related cardiac dysfunction (SRCD) is a severe complication of sepsis with complex pathophysiology involving dysregulated inflammatory responses, immune cell dysfunction, and multiple forms of programmed cell death. The review addresses the core pathophysiological mechanisms of SRCD, the central role of immune cell crosstalk (particularly between macrophages and neutrophils), and the evaluation of multi-target therapeutic strategies with an emphasis on natural compounds. We highlight promising interventions, including ginsenosides and melatonin, which exert multi-target protective effects. Future research should integrate insights across these themes to accelerate the development of precise therapies and improve patient survival and quality of life.
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Gao et al. (2026) conducted a review in Sepsis-related cardiac dysfunction (SRCD). Natural compounds (e.g., ginsenosides, melatonin) was evaluated. Natural compounds, including ginsenosides and melatonin, demonstrate therapeutic potential for sepsis-related cardiac dysfunction by modulating immune cell crosstalk and inhibiting cell death.
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