A Network Meta-Analysis of Comparative Effectiveness and Safety of Pulsed Field, Radiofrequency, and Cryoballoon Ablation for Atrial Fibrillation

Figures

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  Figure 1. Network meta-analysis depicting the primary outcome of recurrence of atrial arrhythmias. Top left:Network geometry showing direct comparisons among different modalities; edge thickness corresponds to the number of studies. Top right:P-score heat map ranking treatments (lower P-scores indicate greater efficacy). Bottom:Comparison-wise pooled OR with 95% CI. CI = confidence interval; OR = odds ratio.

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  Figure 2. Comparison-wise effect plot displaying pooled OR with 95% CI. A:Atrial arrhythmia recurrence in the paroxysmal AF subgroup of patients. B:Atrial fibrillation recurrence in patients with overall AF. C:Atrial tachycardia/atrial flutter recurrence in patients with overall AF. AF = atrial fibrillation; CI = confidence interval; OR = odds ratio.

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  Figure 3. Network meta-analysis for the outcome of peri-procedural complications. Top left:Network geometry of direct comparisons among different modalities; edge thickness reflects study count. Top right:P-score heat map (lower P-scores indicate a more favorable safety profile). Bottom:Comparison-wise pooled OR with 95% CI. CI = confidence interval; OR = odds ratio.

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  Figure 4. Network meta-analysis for the outcome of pericardial complications. Top left:Network geometry of direct comparisons among different modalities; edge thickness reflects study count. Top right:P-score heat map (lower P-scores indicate a more favorable safety profile). Bottom:Comparison-wise pooled OR with 95% CI. CI = confidence interval; OR = odds ratio.

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  Figure 5. Network meta-analysis for the outcome of procedure time. Top left:Network geometry of direct comparisons among different modalities; edge thickness reflects study count. Top right:P-score heat map (lower P-scores indicate shorter procedure duration). Bottom:Comparison-wise pooled MD with 95% CI. CI = confidence interval; MD = mean difference.

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  Figure 6. Network meta-analysis for the outcome of fluoroscopy time. Top left:Network geometry of direct comparisons among different modalities; edge thickness reflects study count. Top right:P-score heat map (lower P-scores indicate shorter fluoroscopy time and reduced radiation exposure). Bottom:Comparison-wise pooled MD with 95% CI. CI = confidence interval; MD = mean difference.