Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons

Jay English; Danny McSweeney; Jinghui Geng; Ethan Howell; Fumiko Ribbe; Matthew Hinderhofer; Lydia Proskauer; Rebecca Sebastian; Le Wang; Tal Sharf; Zhiping P. Pang; ChangHui Pak

doi:10.1016/j.celrep.2026.117115

March 21, 2026Cell ReportsOpen Access

Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons

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Key Points

The research investigates how NRXN1 deletions affect synaptic function in neurons derived from induced pluripotent stem cells.
Utilized iPSC-derived neurons with NRXN1 deletion
Analyzed synaptic characteristics related to autism spectrum disorder
Evaluated synaptic characteristics related to schizophrenia
Identified distinct synaptic phenotypes associated with autism spectrum disorder
Identified separate synaptic phenotypes linked to schizophrenia
Demonstrated that disorder backgrounds influence synaptic mechanisms

Implication

English et al. demonstrate that NRXN1 deletion alters synaptic phenotypes in iPSC-derived neurons, indicating disorder-specific mechanisms.

Abstract

English et al. demonstrate that NRXN1deletion iPSC-derived neurons exhibit distinct autism spectrum disorder-and schizophrenia-related synaptic phenotypes

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Cite This Study

English et al. (2026) studied this question.

synapsesocial.com/papers/69c0e029fddb9876e79c1b62 https://doi.org/10.1016/j.celrep.2026.117115

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Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons

Key Points

Implication

Abstract

Discussion

Cite This Study

Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons

Key Points

Implication

Abstract

Discussion

Cite This Study

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