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March 24, 2026EBioMedicine5 citationsOpen Access

PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways

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WGWenjing GuJohns Hopkins UniversityRWRongjun WanZCZhifeng ChenFujian Medical University

Key Points

  • The study aims to explore the role of ppar-γ in macrophage senescence and its impact on allergic airway inflammation.
  • Investigated the effects of ppar-γ on macrophage senescence
  • Analyzed lipid metabolic pathways involved in inflammatory response
  • Conducted experiments assessing airway inflammation in model organisms
  • Ppar-γ effectively suppresses macrophage senescence
  • Reduced allergic airway inflammation observed with ppar-γ activation
  • Alterations in lipid metabolic pathways correlated with decreased inflammation

Abstract

US National Institutes of Health (NIH) (1R01AI153331 and R01AI141642 to Dr. Gao), Anhui Provincial Key projects of Natural Science Foundation for Colleges and Universities 2025AHGXZK31476 (Dr. Wan).

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Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d383ahttps://doi.org/10.1016/j.ebiom.2026.106226
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