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March 24, 2026Journal of Nanobiotechnology2 citationsOpen Access

Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus

PJPeitong JiangLWLi WangYSYun Sun

Key Points

  • The research aims to develop a targeted nucleic acid delivery system to combat multidrug-resistant Staphylococcus aureus infections.
  • Utilized a tetrahedral framework nucleic acid platform for drug delivery
  • Incorporated aptamers to target specific bacterial strains
  • Evaluated antimicrobial efficacy against biofilm-producing bacteria
  • Assessed immunomodulatory effects in skin infection models.
  • Demonstrated effective delivery of emodin, an antimicrobial agent
  • Significantly disrupted biofilm formation associated with bacterial infections
  • Showed improved anti-inflammatory response in host tissues

Abstract

Overall, this study establishes an aptamer-targeted nucleic acid nanoplatform that integrates antimicrobial delivery, biofilm disruption, and host immunomodulation, offering a promising therapeutic strategy for multidrug-resistant S. aureus skin infections.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d39a8https://doi.org/10.1186/s12951-026-04278-5
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