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March 24, 2026Bulletin of KSAU

Betulinic Acid Amide Effect on the Immune Status of Guinea Pigs Infected With BLV

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Authors

NNNatalia NovikovaKBKsenia V. BarminaVVVasiliy Vlasenko

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Overview

Experimental evaluation finds improved immune responses in guinea pigs infected with BLV after betulinic acid amide treatment, suggesting implications for veterinary medicine.

Key Points

  • This research aims to assess the impact of betulinic acid amide on immune responses in guinea pigs infected with bovine leukemia virus.
  • Conducted with 25 guinea pigs divided into 5 groups
  • Groups 1–4 were infected with BLV, while group 5 served as a negative control
  • Administered betulinic acid amide subcutaneously in varying schedules relative to infection
  • Collected blood samples for immune status assessment at 45 and 90 days
  • Utilized immunofluorescence assays to measure immune responses.
  • Significant increase in leukocyte count by 1.25 times by day 90
  • 1.5- to 5.5-fold increase in lymphoid cells due to B-lymphocyte and cytotoxic T-lymphocyte proliferation
  • Administration of the drug inhibited lymphocyte proliferation and reduced antibody titers
  • 80% of guinea pigs showed absence of BLV after treatment
  • Geometric mean antibody titer decreased by 1.86-fold.

Cite This Study

Novikova et al. (2026) studied this question.

synapsesocial.com/papers/69c2295caeb5a845df0d3b6fhttps://doi.org/10.36718/1819-4036-2026-2-150-160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Pyridine Compounds on the Biochemical Status of Blood in Guinea Pigs Infected with BLV2025
  2. 2NEUTROPHILS FUNCTIONAL STATE IN GUINEA PIGS IMMUNIZED WITH EXPERIMENTAL CONJUGATES AFTER SENSITIZATION WITH MYCOBACTERIUM SMEGMATIS2025
  3. 3BLV coinfection impairs immunity and diagnostics in bovine tuberculosis2025
  4. 4Studying immunotherapeutic properties of the conjugate based on BCG antigens with betulonic acid in guinea pigs infected with <i>Mycobacterium scrofulaceum</i>2024 · 1 citations
  5. 5Cytotoxic T-lymphocyte antigen 4 and programmed cell death ligand 1 blockade increases the effectiveness of interleukin-15 immunotherapy in a bovine leukemia model2024