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Synapse
June 18, 2002Circulation356 citationsOpen Access

Mental Stress Induces Prolonged Endothelial Dysfunction via Endothelin-A Receptors

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LSLukas E. SpiekerDHDavid HürlimannFRFrank Ruschitzka

Structured PICO

Does selective endothelin-A receptor antagonism prevent prolonged endothelial dysfunction induced by mental stress?

I
Intervention
Selective endothelin-A receptor antagonism
O
Outcome
Prolonged endothelial dysfunctionsurrogate

Selective endothelin-A receptor antagonism prevents mental stress-induced prolonged endothelial dysfunction, providing a novel link to atherosclerotic vascular disease.

Abstract

Mental stress induces prolonged endothelial dysfunction, which is prevented by selective endothelin-A receptor antagonism. This represents a novel and important link between mental stress and atherosclerotic vascular disease.

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Cite This Study

Spieker et al. (2002) studied this question.

synapsesocial.com/papers/69c30281a77124f241cab4f6https://doi.org/10.1161/01.cir.0000021598.15895.34
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