Why the study?
Does selective endothelin-A receptor antagonism prevent prolonged endothelial dysfunction induced by mental stress?
Does selective endothelin-A receptor antagonism prevent prolonged endothelial dysfunction induced by mental stress?
Selective endothelin-A receptor antagonism prevents mental stress-induced prolonged endothelial dysfunction, providing a novel link to atherosclerotic vascular disease.
May suggest endothelin-A antagonism for stress-related vascular risk; leaves open translation to clinical outcomes.
Mental stress induces prolonged endothelial dysfunction, which is prevented by selective endothelin-A receptor antagonism. This represents a novel and important link between mental stress and atherosclerotic vascular disease.
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Spieker et al. (2002) studied this question.
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