Demonstrates that targeting the PTTG3P/miR-142-5p/IGF2BP3 axis sensitizes hepatocellular carcinoma to ferroptosis, suggesting a novel therapeutic target.
The PTTG3P/miR-142-5p/IGF2BP3 axis is a master regulator of ferroptosis in HCC. PTTG3P is a competing endogenous RNA (ceRNA) which sustains IGF2BP3-mediated ferroptosis resistance. Targeting the axis sensitizes HCC to ferroptosis and is potentially a novel therapeutic target to combat treatment resistance.
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Zhang et al. (2026) studied this question.
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