Dapagliflozin and Crocin Ameliorate DOX-Induced Cardiotoxicity in Rats via Activating the Nrf-2/HO-1/NQO1 Pathway: A Comparative Study

Key Points

• To compare the cardioprotective effects of dapagliflozin and crocin against doxorubicin-induced cardiotoxicity in rats.
• Animal model of rat induced with doxorubicin to assess cardiotoxicity
• Treatment groups receiving either dapagliflozin or crocin
• Measurement of oxidative stress and related gene expression levels
• Dapagliflozin significantly reduced markers of oxidative stress compared to crocin
• Apoptosis rates decreased more effectively in the dapagliflozin group
• Nrf-2, HO-1, and NQO1 gene expressions were upregulated with dapagliflozin treatment