Preoperative First-line Amlodipine in Pheochromocytoma/Paraganglioma: Perioperative Haemodynamic Instability and Its Predictors
Key Points
This research aims to evaluate the effectiveness of amlodipine in preventing hemodynamic instability in patients with pheochromocytoma and paraganglioma.
Administered amlodipine as a first-line treatment preoperatively.
Monitored plasma levels of metanephrine and normetanephrine.
Assessed hemodynamic stability during surgery.
Amlodipine significantly reduced incidence of intraoperative hypertension.
Elevated plasma free metanephrine levels correlated with higher rates of intraoperative hypertension.
Postoperative hypotension was linked to increased levels of normetanephrine.
Abstract
First-line amlodipine blockade was effective in preventing iHDI in PPGL. Plasma free metanephrine and normetanephrine correlated with intraoperative hypertension and postoperative hypotension, respectively.