Type I Photosensitizers Responsive Self-Immolative Polymers: Combining Drug Release with Photodynamic Therapy

Puntos clave

• The aim is to develop self-immolative polymeric micelles that release drugs in response to superoxide anions from Type I photosensitizers.
• Synthesis of self-immolative polymeric micelles (SIPMs)
• Evaluation of cascade degradation triggered by superoxide anions
• Testing drug release efficiency under light exposure
• SIPMs effectively degraded upon exposure to superoxide anions
• Controlled drug release was observed under conditions mimicking photodynamic therapy
• The combination of SIPMs with Type I photosensitizers enhanced therapeutic outcomes

Resumen