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Retrospective analysis reveals visual outcomes linked to biomarkers in Wolfram Syndrome Type 1, suggesting genetic screening.
OA was the most common and sometimes earliest WS1 manifestation. Correlations between BCVA, OCT metrics, and mutation severity score support their potential value as biomarkers and prognostic tools. Findings also support considering genetic screening for WFS1 mutations in patients presenting with otherwise unexplained OA.
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McNeely et al. (2026) studied this question.
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