Transcriptomic analysis reveals lipid metabolism and macrophage involvement in lung fibrosis, suggesting new research avenues.
The study highlighted two distinct protective effects of nintedanib on lung fibrosis. One well-known on mesenchymal cells and matrix-related components. Plus, one related to the involvement of the pneumocyte-macrophage paracrine lipid axis, where oxidized lipids alter macrophage activities, leading to the formation of lipid-filled macrophages. This may open new research directions.
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Bonatti et al. (2026) studied this question.
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