Crosslinker Nanocarriers-based Intratumoral Delivery for Protein Complex Mapping in Mitochondria of Live Tumor-Bearing Mice

Key Points

• To investigate protein interactions within mitochondria of live tumor-bearing mice using crosslinker nanocarriers.
• Utilized crosslinking mass spectrometry for protein analysis.
• Delivered protein complexes intratumorally via nanocarriers.
• Performed in vivo studies with live tumor-bearing mice.
• Expanded understanding of mitochondrial protein interactions in tumors.
• Revealed specific protein complexes associated with tumor metabolism.
• Demonstrated effective targeting of mitochondria using nanocarriers.