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January 1, 2026RSC AdvancesOpen Access

Direct access to ligand-like sulfonamide libraries via acid-catalyzed sulfinamide crossover

Vladimír Nosek Anna Šimková Jiří Míšek

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Key Points

The aim is to develop a method to create diverse libraries of sulfonamides for identifying factor Xa ligands.
Utilized sulfinamide S–N crossover technique
Employed acid-catalysis
Synthesized diverse sulfonamide libraries
Successfully generated diverse ligand libraries
Achieved oxidative locking of sulfonamides
Enabled discovery of factor Xa ligands through AS-MS techniques

Implication

This research demonstrates diverse ligand libraries in sulfonamides, highlighting a novel discovery method for factor Xa ligands.

Abstract

Sulfinamide S–N crossover builds diverse libraries, oxidatively locks sulfonamides, and enables AS-MS discovery of factor Xa ligands.

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Cite This Study

Nosek et al. (2026) studied this question.

synapsesocial.com/papers/69c37b33b34aaaeb1a67d650 https://doi.org/10.1039/d6ra00651e

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