Peri-Umbilicated Pseudopustules in Mpox

Abstract Mpox is an emerging zoonotic infection that has shown sustained human-to-human transmission since 2022, often through sexual contact networks. We report a case of mpox in a 43-year-old Indian-origin man residing in the United Arab Emirates who presented with fever, sore throat, and a painful genital ulcer, followed by widespread vesiculo-pseudopustular lesions. Examination revealed firm, well-circumscribed, peri-umbilicated pseudopustules, distinctive lesions lacking purulent content. Laboratory investigations were unremarkable, and a polymerase chain reaction test for the Monkeypox virus, conducted on throat and skin swabs, confirmed the diagnosis. The patient was managed with supportive care and recovered uneventfully. This case highlights the characteristic pseudopustular morphology of mpox, which serves as a key diagnostic clue distinguishing it from other genital and vesicular eruptions, and underscores the need for clinicians to be aware of this condition amid evolving global epidemiology.