Genome sequencing reveals a protease-free Bacillus subtilis strain, enhancing recombinant protein production efficiency.
Bacillus strains efficiently secrete heterologous recombinant proteins as well as multiple proteases, with the latter destroying the former. Strains deleted of multiple secreted proteases are, therefore, preferred as protein expression hosts. We report the genome sequence of one such easily available strain, Bacillus subtilis KO7-S.
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Bothra et al. (2026) studied this question.
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