Meta‐Analysis: PPAR Agonists for Pruritus and Quality of Life in Primary Biliary Cholangitis

Key Points

• This analysis aims to evaluate the efficacy of PPAR agonists on pruritus and quality of life in patients with primary biliary cholangitis.
• Conducted a meta-analysis of clinical trials involving PPAR agonists
• Focused on symptoms of pruritus and quality of life metrics
• Included studies reporting itch-specific outcomes
• PPAR agonists decreased the severity of pruritus in patients with moderate-to-severe symptoms
• Improvement in itch-specific outcomes was consistent
• Uncertainty remains regarding overall quality of life improvements