Demonstrates that Gorab deficiencies accelerate skin aging in the dermis, suggesting targeted interventions may mitigate effects.
This study elucidates that Gorab mutations in the dermis promote skin aging by causing P53 accumulation and disrupting ECM expression via epigenetic regulation. These findings clarify the biological role of Gorab in skin aging and provide a theoretical basis for related mechanistic research and potential preventive strategies.
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Li et al. (2026) studied this question.
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