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March 25, 2026Open Access

In vitro and in vivo sonoporation using hard-shelled poly (n-butyl cyanoacrylate) microbubbles to improve drug delivery to breast cancer

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Authors

JBJulia Karoline Blöck

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Overview

Research demonstrates enhanced drug delivery in cancer therapy using ultrasound-activated microbubbles, suggesting improved treatment outcomes.

Key Points

  • The aim is to improve drug delivery through sonoporation using narrow size-distributed poly(n-butyl cyanoacrylate) microbubbles.
  • Characterized the ultrasound response of poly(n-butyl cyanoacrylate) microbubbles.
  • Compared the in vitro performance of ultrasound-activated PBCA microbubbles with commonly used microbubble types.
  • Injected drug-like macromolecules into cells and tumor-bearing mice for validation of findings.
  • Assessed the impact of ultrasound and PBCA microbubbles on drug extravasation and tumor growth.
  • PBCA microbubbles were responsive to ultrasound above 165 kPa, bursting at 500 kPa.
  • Significant biological effects were observed in in vitro cell experiments using PBCA microbubbles.
  • Ultrasound with PBCA microbubbles enhanced macromolecule extravasation into tumor tissue by up to 36 µm from blood vessels.
  • Combined treatment with PBCA microbubbles and a commercial chemotherapeutic agent effectively inhibited tumor growth.

Cite This Study

Julia Karoline Blöck (2025) studied this question.

synapsesocial.com/papers/69c37bd4b34aaaeb1a67e901https://doi.org/10.18154/rwth-2026-01178
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