Key result
Biomechanical forces and hemodynamic cues regulate multiple critical steps of AV valve development.
Why the study?
Errors in atrioventricular valve development can cause congenital valve disease, and increasing evidence suggests hemodynamic cues are required across multiple developmental steps.
Design
Review
This review summarizes how biomechanical forces and hemodynamic cues regulate the multi-step process of atrioventricular valve formation, providing insights into the origins of congenital valve disease.
Atrioventricular valves prevent the backward flow of blood from the ventricles to the atria and are essential for the efficient pumping of blood throughout the body. Errors in development can lead to congenital atrioventricular valve disease. Atrioventricular valve formation is a multi-step process that involves endocardial cushion formation, valve progenitor cell proliferation, valve sinus formation, valve elongation, and extracellular matrix remodeling. Increasing evidence suggests that hemodynamic cues are required across multiple steps. Here, we compare atrioventricular valve formation in different in vivo models and review how biomechanical forces regulate atrioventricular valve formation.
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Yang et al. (2026) studied this question. Biomechanical forces and hemodynamic cues are essential regulators across multiple critical steps of atrioventricular valve formation and development.
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