A high affinity dopamine aptamer: implications of library diversity and negative selections

Yi Yu; Y. S. Li; Juewen Liu

doi:10.1039/d5sc09660j

January 1, 2026Chemical ScienceOpen Access

A high affinity dopamine aptamer: implications of library diversity and negative selections

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Key Points

This research investigates the effects of library diversity and the absence of negative selections on the affinity of dopamine aptamers.
Conducted selection experiments for dopamine aptamers under controlled conditions.
Compared outcomes with previous experiments that included negative selections.
Analyzed the impact of increased library diversity on aptamer affinity.
Identified a new dopamine aptamer with high affinity despite lacking negative selection steps.
Demonstrated that library diversity influences the effectiveness of aptamer selection.
Found that the absence of negative selections still allowed for successful dopamine binding.

Implication

Selection experiments reveal how library diversity and negative selections impact aptamer affinity for dopamine.

Abstract

In 2018, a DNA aptamer for dopamine was selected after extensive negative selection steps. Herein, a new selection experiment was carried out under the same conditions except that no negative...

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69c37bf3b34aaaeb1a67ecb8 https://doi.org/10.1039/d5sc09660j

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A high affinity dopamine aptamer: implications of library diversity and negative selections

Key Points

Implication

Abstract

Discussion

Cite This Study

A high affinity dopamine aptamer: implications of library diversity and negative selections

Key Points

Implication

Abstract

Discussion

Cite This Study

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