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March 25, 2026Asian Journal of Pharmaceutical Research and Health CareOpen Access

Reverse-phase High-performance Liquid Chromatography: High-performance Liquid Chromatography Method Used for Estimating Cefuroxime Axetil in Tablet and Bulk Dosage Formulations

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Authors

CBChinnam Naidu BottaSRShaik ReehanaKRK. Ravishankar

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Overview

Develops an accurate RP-HPLC method to quantify cefuroxime axetil in medications, suggesting it’s effective for quality control.

Key Points

  • This research aims to develop and validate a rapid and accurate RP-HPLC method for quantifying cefuroxime axetil in pharmaceutical products.
  • Utilized a BDS-Hyperil C8 column for chromatography with acetonitrile and water as a mobile phase.
  • Conducted analyses at a wavelength of 277 nm using a Shimadzu-LC-20AT HPLC system.
  • Assessed the method according to ICH guidelines for validity and reliability.
  • Achieved a purity of 99.09% for the marketed formulation of cefuroxime axetil.
  • Demonstrated excellent linearity (R² = 0.9998) in the 30-70 µg/mL range.
  • Observed LOD and LOQ values of 0.0180 µg/mL and 0.0546 µg/mL respectively.
  • Maintained accuracy with % RSD = 0.06 and demonstrated robustness against minor analytical fluctuations.

Cite This Study

Botta et al. (2026) studied this question.

synapsesocial.com/papers/69c37bf3b34aaaeb1a67ee10https://doi.org/10.4103/ajprhc.ajprhc_92_25
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