Case report demonstrates complete resolution of cryoglobulinemic vasculitis in HBV-HDV coinfection, suggesting effective treatment options.
The global prevalence of hepatitis B virus (HBV) infection is around 257 million people, and about 5% are coinfected with hepatitis delta virus (HDV). HDV infection can progress from acute fulminant hepatitis to chronic hepatitis, cirrhosis, or hepatocellular carcinoma. About 20% of HBV patients develop extrahepatic manifestations; among them, cryoglobulinemic vasculitis (CV) occurs in less than 5% of cases and can lead to heterogeneous clinical manifestations. We present the case of a woman with HBV-HDV coinfection who was referred to our clinic with suspected virus-related CV. One-year treatment with bulevirtide led to complete and durable resolution of CV.
No takes yet. Share an insight, caveat, or question.
Geremicca et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: