Glucagon-like peptide agonists and use in short bowel syndrome – what about the side effects?

Lucy Gorard; Megan Boucher; Charlotte Rutter

doi:10.1097/mog.0000000000001169

March 23, 2026Current Opinion in Gastroenterology

Glucagon-like peptide agonists and use in short bowel syndrome – what about the side effects?

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Key Points

To explore the role of GLP-2 and GLP-1 agonists in managing short bowel syndrome and their associated side effects.
Review of current GLP-2 agonist therapies in short bowel syndrome management.
Discussion of potential GLP-1 agonists as complementary treatments.
Analysis of long-term studies and registry data for patient safety and treatment personalization.
GLP-2 agonists are integral in managing short bowel syndrome.
GLP-1 therapies may help reduce dependency on parenteral support (PS).
Continued research is needed for optimal patient selection and safety monitoring.

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Implication

Long-term studies examine side effects of GLP agonists in short bowel syndrome, suggesting safer treatment options.

Abstract

While GLP-2 agonists shape the current landscape of SBS management, GLP-1 based therapies may complement future treatment strategies offering the potential to reduce or even eliminate dependence on PS. Continued long-term studies and registry data are essential to optimize patient selection, safety monitoring, and personalized use of GLP agonists.

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Gorard et al. (2026) studied this question.

synapsesocial.com/papers/69c37c33b34aaaeb1a67ef69 https://doi.org/10.1097/mog.0000000000001169

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Glucagon-like peptide agonists and use in short bowel syndrome – what about the side effects?

Key Points

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Abstract

Discussion

Cite This Study

Glucagon-like peptide agonists and use in short bowel syndrome – what about the side effects?

Key Points

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Implication

Abstract

Discussion

Cite This Study

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