693 HER2 Discordance Between Primary and Metastatic Gastric Cancer: A Systematic Review and Meta-Analysis | Synapse
March 26, 2026Open Access
693 HER2 Discordance Between Primary and Metastatic Gastric Cancer: A Systematic Review and Meta-Analysis
Key Points
To evaluate HER2 expression differences between primary and metastatic gastric cancer samples.
Conducted a systematic review
Performed a meta-analysis
Analyzed HER2 status in primary vs metastatic tissues
Stratified findings based on immunological characteristics.
Identified significant discordance in HER2 expression rates
Highlighted variations based on inflammation levels
Indicated implications for targeted therapies in gastric cancer.
Abstract
Conclusions: aSCC shows a myeloid enriched, developed T cell milieu vs HSIL/NDE.Stratifying SCC by T cell inflammation reveals tighter epithelial-T cell and myeloid-T cell coupling in Hot tu