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March 1, 2026Journal of InfectionOpen Access

Hypervirulent Klebsiella pneumoniae Defined by a Five-Gene Panel Predicts Mortality in Community-Acquired Bacteremia

Feng-Yee Chang L. Kristopher Siu Jung-Chung Lin Rui‐Xin Wu Yu-Kuo Tsai Esther Yip-Mei Liu Chang-Phone Fung Sheng-Kang Chiu Ching-Hsun Wang

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Key Points

To evaluate the clinical relevance of a five-gene definition distinguishing hypervirulent Klebsiella pneumoniae.
Conducted a longitudinal study in an hvKp-endemic region.
Classified isolates as hypervirulent or classical using PCR detection.
Compared clinical characteristics and microbiologic features between groups.
Identified predictors of 28-day mortality using logistic regression analysis.
Among 602 patients, 254 had hvKp bacteremia.
hvKp infections showed higher rates of abscess formation and longer hospital stays.
After adjustments, hvKp was an independent predictor of 28-day mortality.
Most hvKp isolates were susceptible to common antimicrobial agents.
cKp isolates with partial virulence genes had comparable characteristics to those lacking all five.

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Implication

Longitudinal study identifies higher mortality in adults with hypervirulent Klebsiella pneumoniae, indicating vital clinical guidance.

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Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc69fdc3bde4489178fe https://doi.org/10.1016/j.jinf.2026.106741

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Detection of Hypervirulence Genes and Drug Resistance in <i>Klebsiella pneumoniae</i> in Diagnostic Microbiology2025 · 6 citations
2Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotypeOriginal Research · 2026
3Hypervirulent Klebsiella pneumoniae (hvKp): Overview, Epidemiology, and Laboratory DetectionReview · 2025 · 68 citations
4Presence of hypervirulence-associated determinants in Klebsiella pneumoniae from hospitalised patients in Germany2024 · 35 citations
5Comparative profiling of virulence determinants, capsular serotypes, and antimicrobial resistance in hypervirulent and classical Klebsiella pneumoniae isolates from liver abscess patientsOriginal Research · 2026

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