Synthetic strategy demonstrates efficient synthesis of 1-benzothiazolyl-o-carboranes, highlighting implications for drug design.
The innovation of synthetic strategies for incorporating heterocycles into carborane is a significant objective in the realm of carborane chemistry on account of the fact that heterocyclic skeletons are widespread among natural products as well as bioactive molecules and the versatility applications of carboranes in medicinal chemistry and materials science. This method disclosed a facile and practical protocol for the synthesis of 1-benzothiazolyl-o-carboranes through an iodosobenzene-mediated intramolecular oxidative annulation process of C(1)-N-arylthioaacylamino-o-carborane. A series of 1-benzothiazolyl-o-carboranes have been synthesized in good to excellent yields. This work would be an important reference for the synthesis of aromatic heterocycle-carborane derivatives and promote their applications in designing drug candidates and functional materials.
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Guo et al. (2026) studied this question.
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