Conserved neutrophil degranulation transcripts in HIV-TB coinfected children across East and Southern Africa

Eric Katagirya; Busisiwe Mlotshwa; Samuel Kyobe; Savannah Mwesigwa; Gaone Retshabile; Lesedi Williams; Marion Amujal; John Mukisa; Gerald Mboowa; David Patrick Kateete; Misaki Wayengera; Sununguko Wata Mpoloka; Angella N. Mirembe; Ishmael Kasvosve; Koketso Morapedi; Makhosazana Dlamini; Betty Nsangi; Grace P. Kisitu; Adeodata R. Kekitiinwa; Gabriel Anabwani; Moses Lutakoome Joloba; Eddie Mujjwiga Wampande; Dithan Kiragga; Florence Anabwani-Richter; Candace Brown; G. Mardon; Neil A. Hanchard; Mogomotsi Matshaba; and for the Collaborative African Genomics Network (CAfGEN); Masego Tsimako- Johnstone; Keofentse Mathuba

doi:10.1038/s43856-025-01284-w

Key Points

The aim is to identify conserved transcriptomic signatures in children coinfected with HIV and TB.
Analyzed whole-blood transcriptomic data from pediatric subjects
Investigated regional variations in transcript isoforms
Identified potential biomarkers for HIV-TB coinfection
A conserved transcriptomic signature was found in children with HIV-TB coinfection
Regional variations at the isoform level were highlighted
The findings support the use of transcriptional analysis for understanding immune responses

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Implication

Research demonstrates conserved transcriptomic signatures in HIV-TB coinfection, suggesting biomarkers in children across Africa.

Abstract

These findings demonstrate a conserved whole-blood transcriptomic signature in pediatric HIV-TB coinfection, while also highlighting regional variation at the isoform level. This supports the use of transcript-level analyses to identify biomarkers and enhance understanding of host responses in diverse African settings.

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Katagirya et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccaffdc3bde4489180aa https://doi.org/10.1038/s43856-025-01284-w

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Conserved neutrophil degranulation transcripts in HIV-TB coinfected children across East and Southern Africa

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Conserved neutrophil degranulation transcripts in HIV-TB coinfected children across East and Southern Africa

Key Points

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Implication

Abstract

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