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March 1, 2026Alzheimer s & Dementia

G‐ALPS: An index for evaluating cognitive decline and aging using diffusion tensor imaging

Ahmadali Jamali Majid Abbasi Sisara Elahe Kazemi Nasab Debby Van Dam Masoud Amiri

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Key Points

The aim is to evaluate cognitive decline and aging through the G-ALPS index, exploring its relation to brain function.
Utilized diffusion tensor imaging to assess brain function.
Developed the G-ALPS index for measuring cognitive decline.
Analyzed the index in relation to the glymphatic system.
The G-ALPS index may serve as an indirect measurement of glymphatic system function or dysfunction.

Implication

Evaluates cognitive decline using the G-ALPS index, suggesting its linkage to the glymphatic system's function.

Abstract

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Cite This Study

Jamali et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccaffdc3bde4489181a3 https://doi.org/10.1002/alz.71118

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Glymphatic system metrics derived from DTI-ALPS are associated with cognitive impairment, brain atrophy, and plasma tauopathy biomarkers of type 2 diabetes patients: Analysis in dual-cohortOriginal Research · 2026
2Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease2024 · 286 citations
3Imaging biomarkers of glymphatic system dysfunction in Alzheimer’s disease: a systematic review and meta-analysis with a focus on DTI-ALPS indexMeta-Analysis · 2026 · 2 citations
4Impaired glymphatic function as a biomarker for subjective cognitive decline: An exploratory dual cohort study2024 · 61 citations
5Glymphatic System Dysfunction as a Predictor of Cognitive Decline and Incident Dementia (P8-12.009)Original Research · 2026

The Association of the Glymphatic Function with amyloid deposition: a clinical stage-specific Approach2025
Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) as a Neuroimaging Biomarker of Glymphatic Function in Neurodegenerative Diseases: A Systematic Review2026
Automated diffusion‐weighted image analysis along the perivascular space index reveals glymphatic dysfunction in association with brain parenchymal lesions2024
ZBP1‐mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stressAlzheimer s & Dementia · 2026
Exposome‐wide association study and predictive risk score for incident Alzheimer's disease and related dementiasAlzheimer s & Dementia · 2026

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