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March 26, 2026Chemical Research in ToxicologyOpen Access

Mitochondrial DNA Damage Induced by Aristolochic Acid I: Recognizing the Heart as a Target Organ

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Authors

HKHong-Ching KwokKCKai ChengWCW. K. Chan

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Overview

Reveals mitochondrial dysfunction in the heart due to aristolochic acid I, suggesting implications for nephropathy.

Key Points

  • The research investigates how aristolochic acid I damages mitochondrial DNA and affects energy levels in the heart.
  • Examined effects of prolonged exposure to aristolochic acid I in mice.
  • Measured oxidative stress levels, mitochondrial DNA copy numbers, and ATP levels in heart, kidneys, and liver.
  • Analyzed AA-DNA adducts in kidney mtDNA.
  • Prolonged exposure to AA-I increases oxidative stress levels in the heart and kidneys.
  • Significant decreases in ATP levels were found specifically in the heart and kidneys.
  • High levels of AA-DNA adducts were detected in kidney mitochondrial DNA.

Cite This Study

Kwok et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde448918504https://doi.org/10.1021/acs.chemrestox.6c00060
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know2024 · 1 citations
  2. 2Sex-specific toxicity targets of aristolochic acids: nephrotoxicity in males, hepatotoxicity in females2026 · 2 citations
  3. 3Nephropathy induced by Aristolochic Acid.2024
  4. 4Toxicological evaluation of aristolochic acid II following single and repeated oral administration over a 24-week period2025
  5. 5Toxicological evaluation of aristolochic acid II following single and repeated oral administration over a 24-week period2025