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March 26, 2026Science Signaling0 citations

RXRα marks the spot for Crohn’s disease

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WWWei Wong

Key Points

  • The aim is to explore the role of RXRα in Crohn’s disease and how dietary factors influence its activation.
  • Analyzed the effects of polyunsaturated fatty acids
  • Investigated RXRα signaling pathways
  • Examined disease mechanisms related to Crohn's disease
  • Polyunsaturated fatty acids significantly activate RXRα
  • Increased RXRα activity correlates with Crohn’s disease pathogenesis
  • Western diet components worsen disease progression

Abstract

Polyunsaturated fatty acids in a Western diet activate RXRα to promote Crohn’s disease pathogenesis.

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Cite This Study

Wei Wong (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde448918570https://doi.org/10.1126/scisignal.aeh3241
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