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The Role of the Gut Microbiome in Nicotine Withdrawal and Dependence | Synapse

March 26, 2026Nicotine & Tobacco Research0 citations

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The Role of the Gut Microbiome in Nicotine Withdrawal and Dependence

EKEda KöşeliVirginia Commonwealth University KTKatarzyna M. TycVirginia Commonwealth University BBBelle BuzziVirginia Commonwealth University

Key Points

The study aims to explore how the gut microbiome influences nicotine withdrawal and dependence.
Conducted a fecal transplant experiment
Measured the severity of nicotine withdrawal
Analyzed interactions along the gut-brain axis
Fecal transplant significantly reduced nicotine withdrawal severity
The findings highlight the role of the gut microbiome in nicotine dependence
Potential implications for reducing health risks associated with smoking

Abstract

Our results indicate that under our experimental conditions fecal transplant can reduce the severity of nicotine withdrawal. This suggests that interactions along the gut-brain axis are important for the development of nicotine dependence and might help lower the risk of cancer and other serious health problems in humans.

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Cite This Study

Köşeli et al. (Mon,) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde44891858e https://doi.org/https://doi.org/10.1093/ntr/ntag057